COX-2 inhibitors (Bextra) are part of a larger group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs).Bextra relievs pain and inflammation by limiting the effect of a natural enzyme called COX-2. Unlike the older NSAIDs, however, the new COX-2 inhibitors do not interfere with COX-1, a related enzyme that exerts a protective effect on the lining of the stomach. As a result, Bextra is less likely to cause the bleeding and ulcers that sometimes accompany sustained use of the older NSAIDs.

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